A CRDC research network distributes clinical trial delivery across multiple NHS sites while concentrating governance accountability at the hub. AQ eISF and ePSF are built to give the hub that control: connecting site documentation, pharmacy accountability, and quality governance into one inspection-ready operating layer across every participating site.

Key Takeaways:

• AQ gives every CRDC spoke site one hub-controlled document structure — consistent across all ten sites from a single configuration point
• Document due dates calculate automatically per site initiation date — coordinators open the platform and see exactly what is required and when, without maintaining any tracker
• When a protocol amendment is distributed, the hub sees which sites have acknowledged and which have not — updated in real time as coordinators complete their tasks
• Every signature carries legal attribution, a timestamp, and a SHA-256 document hash. It gives sponsors and MHRA inspectors tamper-proof evidence for every document across the network
• Hub governance leads get a live readiness score, overdue feed, and site comparison matrix across all ten sites. No manual reporting or monitoring visit needed.
• Pharmacy documentation, IP accountability, and dispensing records sit inside the same environment as the investigator site file. Sponsor monitors review everything in one place without requesting packages from site pharmacists
• Any document gap or pharmacy excursion raises a formal CAPA in the moment it is identified — linked to the triggering record, assigned immediately, and visible to the hub quality lead before the site has sent a single email
• Independent verification is enforced before any CAPA can close — every corrective action is confirmed effective, not just marked complete
• Each role — coordinator, quality lead, pharmacist, CRA — gets exactly the view they need without accessing records outside their governance scope
• A permanent, immutable audit trail runs across every site, every module, and every action. So, the network stays inspection-ready every day, not just before an MHRA visit

The Documentation Control Problem Specific to CRDC Research Networks

A CRDC hub is accountable for what happens at every spoke site — but in most networks, it cannot actually see what is happening in real time. Site coordinators maintain their own investigator site files locally. Pharmacy teams manage IP accountability in separate folders. Quality events get escalated by email. The hub finds out about a version gap or an open deviation only when a monitoring visit surfaces it, by which point the issue has often existed for weeks.

This is not a process failure. It is a structural one. When documentation, pharmacy records, and quality activity are managed in disconnected systems across ten sites, the hub has no mechanism for continuous oversight — only periodic reconstruction. AQ eISF and ePSF are designed specifically to close this structural gap: every site works within its own controlled environment, and the hub sees current status across all of them simultaneously, without manual outreach.

Also Read: What is a Clinical Research Delivery Centre (CRDC) and How Does Multi-Site Research Oversight Work?

How AQ eISF Is Built for Multi-Site CRDC Documentation Control

AQ eISF is not simply a digital filing software. It is a document control system built around the specific governance demands of a hub-and-spoke research network — where one hub must maintain oversight of document completeness, version currency, and signature status across ten sites simultaneously, without visiting any of them.